Royal Air Force Typhoon FGR4s have conducted a mission with French aircraft in a joint strike on an subterranean weapons facility in Syria employed by the IS group, according to the UK's MoD.
The facility, identified by reconnaissance, was assessed as housing weapons and explosive materials, the release indicated, and was located in mountainous terrain just north of the ancient city of Palmyra in central Syria.
"Our aircraft employed Paveway IV guided bombs to target a series of access tunnels providing entry to the facility... preliminary assessments indicate the target was engaged successfully," the ministry announced.
There was no evidence of any harm to civilians in the attack late on Saturday and every plane involved returned to base without incident, the defence officials confirmed.
The Typhoon fighters were backed up by a Voyager aerial refuelling aircraft.
The Islamic State group - also known as ISIS - established jihadist rule over parts of Syria and Iraq before its territorial defeat in 2019.
"This operation shows British leadership, and commitment to work closely with our allies, to eradicate any re-emergence of Daesh and their violent and radical beliefs in the region," Britain's Defence Chief the minister said.
RAF aircraft have conducted patrols over Syria to "forestall any attempted comeback" of IS following its routing at the battle of Baghuz in 2019, the ministry said.
"I extend gratitude to the personnel of British forces who took part in this strike for their skill and their courage," the Defence Secretary commented. "They were among a great many British personnel stationed over the holidays. This action, to take out terrorist threats who endanger our security, highlights how our armed forces are always on standby, throughout the year, ensuring Britain's security within its borders and powerful internationally."
During December, the US military executed what it called a "major assault" targeting Daesh sites in the country, following an attack killed two American soldiers and a civilian interpreter in Palmyra.
The UN reports IS still boasts an estimated 5,000 to 7,000 fighters in Syria and Iraq.